Observation of therapeutic effect of nephron sparing surgery on giant renal hamartoma

HOU Yakun; ZHOU Xingyu; Baihetiya·Azati; Mulati·Rexiati; WANG Yujie; WANG Wenguang

doi:10.3969/j.issn.1674-3806.2024.02.13

Abstract：Objective To observe the therapeutic effect of nephron sparing surgery on giant renal hamartoma.Methods The clinical data of 35 patients with giant renal hamartoma who were admitted to the Urinary Surgery Center of the First Teaching Hospital of Xinjiang Medical University for nephron sparing surgery from January 2015 to June 2022 were collected.In all the cases,sufficient renal parenchyma was retained while the tumors were removed by transab-dominal open surgery or laparoscopic resection,and the surgical effects of the patients were summarized and analyzed.Results All the operations were completed successfully in the 35 cases.In the patients undergoing laparoscopic resec-tion,there were no cases of conversion to open surgery and no ruptured bleeding.The operation time was 65-265(139.82± 54.94)minutes and the blood loss was 20-1 100(279.72±310.42)millilitres.The cold ischemia time was 15-65(36.43± 13.92)minutes in 22 cases of open surgery.The warm ischemia time was 20-40(26.47±4.96)minutes in 13 cases of laparoscopic surgery.The serum creatinine value was 36-110(69.99±17.54)μmol/L 3 to 5 days after surgery.The postoperative extubation time was 3-11(4.84±1.63)days,and the postoperative hospitalization time was 4-12(6.71±1.73)days.The renal emission computed tomography(ECT)score of bilateral renal function examination was performed in 18 cases after surgery.The glomerular filtration rate(GFR)of the affected kidneys was 28.7-57.6(37.38± 8.15)mL·min-1·(1.73m2)-1,and during the follow-up of 3-87(46.16±26.97)months,their renal function was normal and no tumor recurrence was found.Conclusion Nephron sparing surgery is safe and feasible for treatment of giant renal hamartoma in technologically mature medical centers.