Current status and evaluation of literature researches on rat models of primary hepatocellular carcinoma
XU Liang
WANG Yaqi
QIAO Jianliang
Abstract：Objective To explore the current status of literature researches on rat models of primary hepato-cellular carcinoma,and to summarize and evaluate these literature researches.Methods The phrases of"primary hep-atocellular carcinoma"and"rat model"were used as key words to retrieve the literature in the China National Knowledge Infrastructure(CNKI)and Wanfang databases.The retrieved papers were indexed by the two databases from January 1996 to December 2021 and 115 pieces of valid literature were included finally.The modeling methods,types and dosages of modeling drugs,modeling cycle and evaluation of the modeling results of the included literature were summarized and analyzed.Results The most commonly used type of primary hepatocellular carcinoma modeling rat was Wistar rat.The main modeling inducers included 7 inducers such as the aqueous solution prepared with diethylnitrosamine(DEN),DEN+sterilized drinking water,DEN+carbon tetrachloride(CCL4),DEN+normal saline,DEN+standard feed,2-acetylaminofluorene(2-AAF)and aflatoxin B1(AFB1),among which the aqueous solution prepared with DEN was the most commonly used,accounting for 63.5％.There were 6 types of modeling methods,including free drinking method,intraperitoneal injection method,intraperitoneal injection+free drinking method,gastric gavage method,subcutaneous injection+free drinking method and intraperitoneal injection+gastric gavage,among which free drinking method was the most commonly used method,accounting for 35.7％.The modeling cycle was 10 weeks to 24 weeks,and the mod-eling results were judged mainly through objective evaluation method,accounting for 47.8％.Conclusion There are various methods for modeling primary hepatocellular carcinoma rats,and there are not unified standard methods at present.Researchers should choose the appropriate modeling method according to their own experimental needs.
Keywords：Primary hepatocellular carcinomarat modelLiterature research
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 192-195 )