Analysis of the early predictive value of TyG index,GLR combined with BISAP score on the severity of hyper-triglyceridemic acute pancreatitis
LI Shuangping
TIAN Xia
BAO Sachula
WU Junyi
HAN Zheng
LIU Meng
Abstract：Objective To analyze the early predictive value of triglyceride-glucose(TyG)index,glucose-to-lymphocyte ratio(GLR)combined with bedside index for severity in acute pancreatitis(BISAP)score on the severity of hypertriglyceridemic acute pancreatitis(HTG-AP).Methods The clinical data of 166 patients with HTG-AP who were admitted to the Wuhan Third Hospital from May 2018 to May 2023 were retrospectively analyzed,including 113 cases in the non-severe group and 53 cases in the severe group.The clinical data collected within 24 hours of admission were compared between the two groups.Multivariate logistic regression was used to analyze the independent influencing fac-tors of severe HTG-AP.Receiver operating characteristic(ROC)curve was used to analyze the efficacy of TyG index,GLR and BISAP score in predicting severe HTG-AP.Results The proportion of the patients with hypertension and dia-betes in the severe group was higher than that in the non-severe group,and the hospital stay in the severe group was longer than that in the non-severe group,and the levels of lymphocytes(LYM)and calcium(Ca2+)in the severe group were lower than those in the non-severe group,and the levels of red blood cell volume distribution width(RDW),D-dimer(DDI),C-reactive protein(CRP),fasting plasma glucose(FPG),total cholesterol(TC),triglyceride(TG),high-density lipo-protein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),TyG index,GLR level,and the BISAP scores in the severe group were higher than those in the non-severe group,and the differences were statistically significant(P＜0.05).The results of multivariate logistic regression analysis showed that higher levels of TyG index,GLR and BISAP score were the independent risk factors for promoting the occurrence of severe HTG-AP(P＜0.05).The results of ROC curve analysis showed that TyG index,GLR and BISAP score all had application value in predicting the occurrence of severe HTG-AP(P＜0.05),and BISAP score combined with TyG index or GLR had better prediction efficacy than a single index.Conclusion TyG index,GLR and BISAP score were correlated with the severity of HTG-AP.TyG index or GLR combined with BISAP score had higher early prediction value for the severity of HTG-AP.
Keywords：Triglyceride-glucose(TyG)indexGlucose-to-lymphocyte ratio(GLR)Bedside index for severity in acute pancreatitis(BISAP)scoreHypertriglyceridemic acute pancreatitis(HTG-AP)
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 167-172 )