Advances in the study of bone marrow mesenchymal stem cells therapy on osteoarthritis
LIU Yuhang
LIN Jinying
Abstract：Osteoarthritis(OA)is one of the most prevalent and highly disabling diseases worldwide,charac-terized by lesions involving the entire joint,including cartilage degeneration,bone remodeling,osteophyte formation,and synovial inflammation.At present,non-operative treatment of OA can not prevent the progression of OA.Bone marrow mesenchymal stem cells(BMSCs)are pluripotent stem cells derived from bone marrow that have the ability of multidirec-tional differentiation,self-proliferation,endocrine and paracrine factors to regulate cell and tissue proliferation,apoptosis,and immune response,etc.They play the role in inducing cell proliferation,stimulating angiogenesis,protecting cells from apoptosis and immune regulation.BMSCs have been increasingly used in the treatment of OA.This paper reviews the research progress of BMSCs in treatment of osteoarthritis in recent years.
Keywords：Osteoarthritis(OA)Bone marrow mesenchymal stem cells(BMSCs)CartilageExo-somes
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 118-122 )