A study on the correlation of serum NLR,hs-CRP and CHI3L1 levels with stroke-associated pneumonia in elderly patients with acute cerebral infarction
YU Baiyang
XU Wu
Abstract：Objective To analyze the correlation of serum neutrophil-to-lymphocyte ratio(NLR),hypersen-sitive C-reactive protein(hs-CRP)and chitinase-3-like protein 1(CHI3L1)levels with stroke-associated pneumonia in elderly patients with acute cerebral infarction(ACI).Methods Four hundred and eighty-seven elderly patients with ACI who were admitted to Taixing People's Hospital from August 2020 to March 2022 were recruited and divided into SAP group(n=139)and non-SAP group(n=348)according to the occurrence of SAP.The clinical data were com-pared between the two groups,and multivariate logistic regression analysis was used to explore the factors affecting the occurrence of SAP in the ACI patients.The efficiency of serum NLR,hs-CRP and CHI3L1 levels in predicting the devel-opment of SAP in the ACI patients was evaluated using receiver operating characteristic(ROC)curve.Results The results of multivariate logistic regression analysis showed that higher levels of baseline of National Institutes of Health Stroke Scale(NIHSS)scores,NLR,hs-CRP and CHI3L1 and occurrence of dysphagia were independent risk factors for SAP in the ACI patients(P＜0.05),while higher baseline of diastolic blood pressure(DBP)was a protective factor against SAP in the ACI patients(P＜0.05).The results of ROC curve analysis showed that serum NLR,hs-CRP and CHI3L1 levels could all effectively predict the occurrence of SAP in the ACI patients(P＜0.05),and the combination of the three indicators could further improve the prediction efficiency[AUC(95％CI)=0.825(0.783-0.868),P＜0.001],and the sensitivity and specificity were 77.04％and 78.28％,respectively.Conclusion The elevated levels of serum NLR,hs-CRP and CHI3L1 are all independent influencing factors for the occurrence of SAP in elderly patients with ACI,and the combined detection of the three indicators has higher predictive value.
Keywords：Acute cerebral infarction(ACI)Stroke-associated pneumonia(SAP)Neutrophil-to-lymphocyte ratio(NLR)Hypersensitive C-reactive protein(hs-CRP)Chitinase-3-like protein 1(CHI3L1)
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 59-64 )