Research progress on the involvement of histone lactylation in regulating tissue damage repair in inflammatory diseases
TANG Yu-jiao
LIU Ru-xin
BAI Xue
Abstract：The pathophysiological mechanisms of inflammatory diseases involve epigenetic regulation.The post-translational modification of histones is an important component of epigenetics,and the lactylated histones derived from lactic acid is a novel post-translational modification of histones discovered in recent years.Immune cells,including macrophages,play an important role in the repair of tissue damage in inflammatory diseases.Histone lactylation mod-ification,as an epigenetic modification,mediates the expression regulation of immune cell repair genes,glycolytic genes,and programmed cell death,thereby participating in the regulation of tissue damage repair in inflammatory diseases.In this paper,the research progress on the involvement of histone lactylation in regulating tissue damage repair in inflam-matory diseases is reviewed.
Keywords：InflammationTissue damage repairHistone lactylationImmune cells
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1308-1312 )