A study on the application value of contrast-enhanced ultrasonography combined with fecal calprotectin detec-tion in assessing the activity of Crohn's disease
CHEN Jing
DONG Zhen-yu
YANG Dong-ye
Abstract：Objective To investigate the application value of contrast-enhanced ultrasonography(CEUS)com-bined with fecal calprotectin(FC)detection in assessing the activity of Crohn's disease(CD).Methods The clinical data of 45 CD patients who were admitted to the University of Hong Kong-Shenzhen Hospital from January 2021 to June 2023 were retrospectively analyzed.According to CD activity index(CDAI)scores,the patients were divided into remission group(＜150 points,18 cases)and active stage group(150-450 points,27 cases).All the patients underwent routine intestinal ultrasonography and CEUS,and FC levels were detected by double antibody sandwich method.Peak inten-sity(PI),area under the curve(AUC)and FC level of the CEUS indicators were analyzed using receiver operating charac-teristic(ROC)curve to assess the activity of CD.Results The indicators of PI and AUC,and the FC level in the remis-sion group were lower than those in the active stage group,and the differences were statistically significant(P＜0.05).The results of Pearson correlation analysis showed that CDAI score was positively correlated with the indicators of PI(r = 0.506,P＜0.001)and AUC(r =0.544,P＜0.001),and the FC(r =0.364,P=0.014)level.The results of ROC curve analysis showed that the indicators of PI and AUC,and the FC level all had application value in assessing the activity of CD(P＜0.05),and the combined assessing efficacy of the three indicators was further improved[AUC(95%CI)= 0.908(0.815-1.000),P＜0.001],and the sensitivity and the specificity were 96.30%and 83.33%,respectively.Conclusion CEUS combined with FC detection can effectively assess the activity of CD,which helps clinicians judge the patients'conditions and timely adjust the appropriate treatment plans.
Keywords：Crohn's disease(CD)Fecal calprotectin(FC)Intestinal ultrasoundContrast-enhanced ultrasonography(CEUS)
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1235-1239 )