Immunotherapy for cold tumors
SU Sheng-chen
Hyung Lae Kim
Abstract：Immunotherapy has joined surgery, radiation, and traditional chemotherapy to become the fourth pillar in cancer treatment. The concept of using one′s own immune system to treat cancer has inspired numerous ther-apies. The class of immunotherapies that has proven most effective is the checkpoint inhibitors( CPIs) , which work by blocking immunosuppressive mechanisms. Prime examples of CPIs in clinical use are based on Nobel Prize winning dis-covery of PD-1/L1 and CTLA-4. The clinical responses to immunotherapies vary, and this is in part due to differences in the tumor microenvironment. Tumors that are poorly infiltrated by lymphocytes are immunologically inert and are referred to as"cold tumors"and tend to respond poorly to CPIs. We review current immunotherapies and examples of efforts to increase lymphocyte infiltration in cold tumors to improve outcomes of CPIs.
Keywords：Cancer immunologyImmunotherapyTumor infiltrating lymphocyte
Publication Date：2021-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 861-870 )