Pathological diagnosis of T-follicular helper cell lymphoma
ZHAO Yue
Jenna McCracken
WANG En-di
Abstract：T-follicular helper cell lymphoma( T-FHCL) is a type of peripheral T-cell lymphoma. The under-standing of T-FHCL has been evolving over the course of several decades, and it was classified into three subcatego-ries by the World Health Organization in 2017. Because T-FHCL often has misleading histopathological manifestations and incompletely clarified pathogenesis, its diagnosis is challenging and usually requires a series of multifaceted eval-uations, especially for angioimmunoblastic T-cell lymphoma( the most common of the three subcategories) . Along with recent advances in the field of molecular biology, the genomic landscape of T-FHCL has been unraveled, and the mecha-nism underlying its lymphomagenesis, especially the development of its unique microenvironment, is now better understood. In this commentary, we not only summarize the pathological features, the updated diagnostic criteria, and classification of T-FHCL, but also discuss the latest advances in the molecular study of T-FHCL and its application in diagnosis and disease classification.
Keywords：T-follicular helper cell lymphomaAngioimmunoblastic T-cell lymphomaFollicular T-cell lymphomaNodal peripheral T-cell lymphoma with T-follicular helper phenotypePeripheral T-cell lymphoma
Publication Date：2021-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 852-860 )