Observation of serum lipid level and oxidative stress response in patients with acute cerebral infarction complicated with helicobacter pylori infection
ZHOU Zhong-xiang
YANG Wen-dong
Abstract：Objective To explore the effect of helicobacter pylori (Hp) infection on blood lipid metabolism and oxidative stress response in patients with acute cerebral infarction (ACI) complicated with Hp infection through the detection of malondialdehyde (MDA) and superoxide dismutase (SOD) activity.Methods Two hundred ACI patients (139 cases of Hp infection and 61 cases of non-infection) were chosen as ACI group and 80 health examinees as control group.The detections of serum Hp-IgG antibody, serum lipid, MDA level and SOD activity, and14C urea breath test (14C-UBT) were performed.Results The Hp infection rate of the ACI group (69.5％) was significantly higher than that of the control group (33.8％) (P＜0.01).In the patients with Hp infection, the levels of TC, TG and LDL-C were significantly higher, and the level of HDL-C was significantly lower than those in the patients without Hp infection (P＜0.01).The serum level of MDA was significantly higher and SOD activity was significantly lower in the Hp infection group than those in the Hp non-infection group (P＜0.01).The serum level of MDA was significantly higher and SOD activity was significantly lower in the Hp non-infection group than those in the control group (P＜0.01).Conclusion Dyslipidemia and oxidative stress reaction are aggravated in the patients with ACI complicated with Hp infection, which may be the cause that aggravates the ACI disease in the patients.
Keywords：Acute cerebral infarction (ACI)Helicobacter pylori (Hp)Blood lipidOxidative stress
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 69-72 )