A clinical analysis of the effect of thyroxine replacement therapy on isolated hypothyroidism during pregnancy
YANG Fang
WANG Su-mei
GONG Xiao-li
Abstract：ObjectiveTo observe the clinical effect of thyroxine replacement therapy on pregnant women with isolated hypothyroxemia.Methods The prospective cohort study was performed in the pregnant women with isolated hyothyroidemia during the first and second trimester who were selected in our outpatients from March 2017 to March 2018.According to whether thyroxine replacement was used, the patients were divided into the intervention group (n=43) and the control group (n=48).The maternal and neonatal outcomes were analyzed.ResultsThere were no significant differences in delivery weeks, delivery methods and postpartum hemorrhage between the two groups (P＞0.05).There were no significant differences in the incidence rates of hypertension, gestational diabetes, fetal growth restriction, premature rupture of fetal membranes and fetal distress between the two groups (P＞0.05).There were no significant differences in neonatal birth weight and the rate of neonatal asphyxia between the two groups (P＞0.05).Conclusion Thyroxine replacement has no significant influences on pregnancy outcomes and perinatal events in pregnant women with isolated hypothyroxemia.
Keywords：PregnancyIsolated hypothyroidismThyroxinePregnancy outcomesPerinatal infants
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 32-35 )