Clinical effect of metformin combined with ethinylestradiol and cyproterone acetate tablets in treatment of polycystic ovary syndrome
TANG Ting-ting
Abstract：Objective To investigate the clinical effect of metformin combined with ethinylestradiol and cyproterone acetate tablets in treatment of polycystic ovary syndrome. Methods The data of 57 patients with polycystic ovary syndrome were collected in our hospital from July 2014 to February 2016 and were retrospectively analyzed. The patients were randomly divided into the observation group(n = 30) and the control group(n = 27). The control group was treated with ethinylestradiol and cyproterone acetate tablets,and the observation group was treated with ethinylestradiol and cyproterone acetate tablets plus metformin. Results The ovulation rate and pregnancy rate of the observation group were higher than those of the control group(93. 33％ vs 81. 48％,83. 33％ vs 55. 56％). After treatment,the improvements of sex hormones in the observation group were significantly better than those in the control group(P < 0. 01). No obvious adverse reactions were found in the two groups. Conclusion Metformin combined with ethinylestradiol and cyproterone acetate is effective in treatment of polycystic ovary syndrome. It can better improve the level of sex hormones and improve the ovulation rate and pregnancy rate in the patients.
Keywords：Polycystic ovary syndromeMetforminEthinylestradiol and cyproterone acetate tabletsSex hormonesAdverse reactions
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 461-463 )