Effects of liraglutide on short-term glucolipid metabolism in patients with primary type 2 diabetes mellitus
LI Jian-ying
Abstract：Objective To observe the clinical effect of liraglutide on newly diagnosed type 2 diabetes mellitus, and to investigate the effects of liraglutide on the patients' blood glucose,blood lipid and body mass index (BMI). Methods During January 2016 and May 2017,20 inpatients with type 2 diabetes mellitus received liraglutide treatment for 4 weeks. During the period of liraglutide treatment,liraglutide was subcutaneously injected to the patients at 0. 6 mg/d during the first week and the dosage was increased to 1. 2 mg/d during the second week and the dosage of 1. 2 mg/d was maintained to the end of the treatment. The changes of blood glucose,blood lipid and BMI were observed before and two and four weeks after treatment. Results Compared with those before treatment,FBG and PBG decreased two weeks after treatment(P < 0. 05), and TG,LDL,BMI,FBG and PBG decreased four weeks after treatment(P < 0. 05). There were no significant changes in TC,HDL,FINS and PINS before and two and four weeks after treatment. Conclusion Liraglutide has significant short-term hypoglycemic and hypolipidemic effects on the patients with newly diagnosed type 2 diabetes,especially on the obese patients with diabetes.
Keywords：LiraglutideDiabetesGlucolipid metabolism
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 454-456 )