Clinical efficacy of aerobic exercise combined with ursodeoxycholic acid in treatment of non-alcoholic fatty liver disease

DUAN Xue-hui; WU Wei-dong; TAN Yan-meng

doi:10.3969/j.issn.1674-3806.2018.05.11

Abstract：Objective To investigate the clinical efficacy of aerobic exercise combined with ursodeoxycholic acid in treatment of non-alcoholic fatty liver disease(NAFLD). Methods 135 patients with NAFLD in our hospital from April 2014 to June 2017 were randomly divided into 3 groups: aerobic exercise group,ursodeoxycholic acid group and aerobic exercise combined with ursodeoxycholic acid group (combined group), with 45 cases in each group. The three groups received the same basic treatment in the outpatient clinic,besides the aerobic exercise group and the ursodeoxycholic acid group were treated with aerobic exercise plus ursodeoxycholic acid capules 250 mg for 3 months,the combined group received ursodeoxycholic acid capules plus aerobic exercise therapy for 3 months. Other 45 healthy subjects were selected as the control group. The changes of body shape(WHR,BMI) were compared among the three groups before and after intervention. The changes of liver function,blood lipid and fatty liver degree were compared among the patients with NAFLD in the three groups before and after intervention. Results After intervention, the WHR indexes in the patients with NAFLD in the three groups were significantly decreased compared with those before intervention(P < 0. 05). There were no significant differences in the BMI indexes among the three groups before and after intervention(P > 0. 05). The clinical total effective rates were 44. 44％,53. 33％ and 77. 78％ in the three group respectively(P < 0. 01). The levels of ALT,AST and gamma-GT in the NAFLD patients of the three groups were significantly decreased compared with those before intervention(P < 0. 05), while HDL-C was increased than that before treatment(P < 0. 05). The fatty liver recovery rates were 8. 89％,22. 22％ and 33. 33％ in the NAFLD patients of the three groups(P < 0. 05). Conclusion The clinical curative effect of aerobic exercise combined with ursodeoxycholic acid is more superior to that of aerobic exercise or using ursodeoxycholic acid alone in treatment of NAFLD. It can effectively improve liver function,reduce blood lipids and improve the patients' quality of life.