The application of dynamic contrast enhanced MRI in the diagnosis of primray hepatocellular carcinoma
KONG Yuan
LI Wen-mei
Abstract：Objective To study the value of dynamic contrast enhanced MRI ( DCE-MRI) in the diagnosis of primary hepatocellular carcinoma .Methods Thirty-nine patients with liver local masses examined by DCE-MRI and verified by pathological findings were divided into 2 groups.The primary hepatocellular carcinoma group (n=27) and the nontumorous nodule group(n=12).Tissue-4D software was used for the post-processing of the DCE-MRI images and the tissue volume perfusion parameters including transfer constant (Ktrans),extravascular extracellular space vol-ume(Ve) and rate constant(Kep) were calculated.Results There were statistically significant differences in Ktrans and Ve between the two groups .The ROC curve had moderate diagnostic value .When the best diagnostic threshold of Ktrans for hepatocellular carcinoma was0.298 min -1, the sensibility was 0.926 and the specificity was 0.750 .When the best diagnostic threshold of Ve for hepatocellular carcinoma was 0.237 , the sensibility was 0.926 and the speci-ficity was 0.500 .Conclusion DCE-MRI can quantificationally analyze microcirculation of the lesion .It provides an effective method for identifying benign and malignant nodules .
Keywords：Dynamic contrast enhanced MRIHepatocellular carcinomaMicrovascular permeabilityPerfusion parameters of tissue
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 387-390 )