Expressions of 8-OHdGa nd phospho-epithelial growth factor receptor in tongue squamous cell carcinoma and their correlation
Abstract：Objective To detect the expressions of 8-hydroxydeoxyguanine(8-OhdG) and phospho-epithelial growth factor receptor ( p-EGFR) in tongue squamous cell carcinoma ( TSCC) and their correlation .Methods The ex-pressions of 8-OHdG and p-EGFR in 30 specimens of tongue squamous cell carcinoma tissues and adjacent -carcinoma tissues were detected by immunohistochemistry .The correlation between 8-OHdG expression and p-EGFR expression was analyzed by Spearman rank correlation analysis .Results Both 8-OHdG and p-EGFR were highly expressed in the TSCC tissues, and their positive rates were 80.0%, 56.7%respectively, whereas the low expressions which were shown with positive rate of 16.7%, 6.7% respectively , were observed in the adjacent-carcinoma tissues .The ex-pressions of 8-OHdG and p-EGFR in carcinoma tissue were significantly higher than those in the adjacent-carcinoma tissue(P<0.05), and the statistically significant correlation was observed between 8-OHdG expression and p-EGFR expression ( P<0.05 ) .Conclusion Reactive oxygen species express in oral cancer , which is positively correlated to p-EGFR.
Keywords：Reactive oxidative species ( ROS )Phospho-epithelial growth factor receptor ( p-EGFR )Tongue squamous cell carcinoma ( TSCC)Immunhistochemistry
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 372-375 )