The expressions of TCF21 and Caspase-3 and their clinical significances in non-small cell lung cancer
Abstract：Objective To investigate the relationship between the expressions of TCF21 and Caspase-3 and the clinicopathological features in non-small cell lung cancer( NSCLC) .Methods 44 samples coming from both ad-jacent and cancer tissues were collected from the People′s Hospital of Binyang County in Guangxi during 2013 to 2015.Real-time PCR(RT-PCR) was used to assay the expressions of TCF21 and Caspase-3 in lung cancer and nor-mal tissues, and the relationship between the expressions of TCF21 and Caspase-3 and the clinicopathological features in NSCLC was analyzed.Results The expressions of TCF21 and Caspase-3 in NSCLC tissues were significantly lower than those in the matched normal lung tissues [ ( 0.36 ±0.70 ) vs ( 1.00 ±0.00 ) , ( 0.62 ±0.56 ) vs ( 1.00 ± 0.00), P<0.05].The levels of TCF21 and Caspase-3 expressions were significantly lower in the mid-term lung cancer TNMⅢthan those in TNMⅠ+Ⅱ[(0.05 ±0.06) vs (0.48 ±0.79), (0.17 ±0.20) vs (0.78 ±0.56), P<0.01].There was a positive correlation between the expressions of TCF21 and Caspase-3 in NSCLC.Conclusion The low expressions of TCF21 and Caspase-3 may aggravate the malignant hyperplasy and metastasis of tumor, com-bined detection of the expressions of TCF21 and Caspase-3 plays an important role in evaluating the degree of malig-nancy, and predicting the potential metastasis and prognosis of NSCLC.
Keywords：Transcription factor 21(TCF21)Caspase-3Non-small cell lung cancer(NSCLC)Ap-optosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 310-312 )