Transabdominal chorionic villus sampling in the invasive prenatal diagnoses：a report of 60 cases

doi:10.3969/j.issn.1674-3806.2016.04.06

Abstract：Objective To summarize the indications and the complications of transabdominal chorionic villus sampling( TA-CVS) in the first trimester of pregnancy.Methods 60 women with single pregnancy came from the outpatient department of obstetrics in our hospital.Their average age was ( 29.27 ± 4.1 ) years, and their average gestational age were (12.61 ±0.86)weeks.The indications of the procedure included the suspicion of the fetal chro-mosomal disorder(20 cases), and coupling with the same type thalassemia carrier(42 cases).The body temperature, blood pressure, and pulse were measured before the TA-CVS.The samples of villi were sent to check the karyotypes, or detect the thalassemia genotypes.Results The homozygote or double heterozygote of β-thalassemia were detected in 6 cases, severeα-thalassemia in 8 cases, and hemoglobin H disease in 6 cases.Autosomal trisomy was detected in 3 cases out of 7 fetus edema/cystic hydroma by B ultrasound.Miscarriage occurred in 1 case two weeks after doing the procedure(1.67%).Conclusion Early diagnosis, timely intervention and low fetal-loss are the advantages of TA-CVS for invasive prenatal examination.The main indications of TA-CVS are the prenatal diagnosis of single genet-ic disease, and chromosomal disorders especially when the ultrasound findings show the suspicious disorders in the first trimester of pregnancy.