Interventional effect of aspirin combined with clopidogrel on symptomatic mild carotid artery stenosis
GONG Yu
WEN Dan
SONG Zhi-jie
Abstract：Objective To study the interventional effect of aspirin combined with clopidogrel on symptomatic mild carotid artery stenosis.Methods One hundred and twenty-six patients with symptomatic carotid artery stenosis in our hospital from April 2013 to November 2014 were taken as the research subjects and randomly divided into the combination group(n=63) and the control group(n=63).All the patients were treated with oral clopidogrel, 75 mg/d.The combined group was treated with aspirin(100 mg/d) at the same time.The two groups were treated for 3 months.The curative effects and incidence of adverse reactions were compared between the two groups.The carotid intima media thickness(IMT) was compared before and after the treatment in both of the two groups.Results 28 ca-ses were markedly effective, 24 cases effective and 11 cases ineffective in the combination group while, 18 cases were markedly effective, 23 cases effective and 22 cases ineffective in the control group.There was a significant difference in curative effect between the two groups(P<0.05);After the medication, the IMT values of both the two groups de-creased significantly(P<0.05); There was no significant differenc in IMT between the combination group(0.75 ± 0.12)mm and the control group(0.79 ±0.15)mm(P>0.05).There was no significant difference in the incidence of adverse reactions between the combination group(47.6%) and the control group(33.3%)(P>0.05).Conclusion Aspirin combined with clopidogrel is safe and effective in the treatment of symptomatic mild carotid artery stenosis.
Keywords：AspirinClopidogrelSymptomatic mild carotid artery stenosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 291-293 )