The effects of Shengjing capsules in combination with Levocarnitine on DNA and acrosome intact rate of sperms and outcomes in vitro fertilization cycles

doi:10.3969/j.issn.1674-3806.2016.04.01

Abstract：Objecit ve To explore the effects of Shengjing capsules in combination with Levocarnitine on DNA fragmentation index( DFI) and acrosome intact rate of sperms and outcomes in vitro fertilization cycles.Methods The DFI, acrosome intact rate and clinical outcomes of 322 infertility male patients were analysed retrospectively ac-cording to the different treatment protocals.Group A( n=96) was treated with Shengjing capsules, and group B( n=103) received Levocarnitine.Group C ( n=123 ) was given Shengjing capsules combined with Levocarnitine.The three groups were performed in vitro fertilization(IVF) three months after the treatment.Results (1)The sperm DNA integrity rate , sperm acrosome intact rate, fertilization rate, good-quality embryo rate and the clinical pregnancy rate in group C were significantly higher than those in group A and group B(P<0.05).(2)There were no significant differences in the cleavage rates among the three groups(P>0.05).(3)The sperm acrosome intact rate, fertilization rate, good-quality embryo rate, clinical pregnancy rate in group A were significantly higher than those in group B(P<0.05).There was no significant difference in sperm DNA integrity rate between group A and group B(P>0.05).(4) The clinical pregnancy rate was 51.2%, 45.8% and 39.8% in group C, group B and group A respectively ( P>0.05).Conclusion Sperm acrosome intact rate, good-quality embryo rate and clinical pregnancy rate in infertility male patients treated with Shengjing capsules were improved better than those with Levocarnitine;the sperm DNA in-tegrity rate, acrosome intact rate, fertilization rate, good-quality embryo rate and clinical pregnancy rate were im-proved better in the patients treated with Shengjing capsules in combination with Levocarnitine than those with Shengjing capsules or Levocarnitine.