The clinical effect of Alprostadil combined with Mecobalamin on Wanger 1~3 level of type 2 diabetic foot

ZOU Wen-bing

doi:10.3969/j.issn.1674-3806.2016.03.13

Abstract：Objective To evaluate the effects of Alprostadil combined with Mecobalamin on Wanger 1~3 level of type 2 Diabetic foot ( DF) .Methods Fifty-two patients with Wanger 1~3 level of type 2 DF were randomly divided into the treatment group(n=26) and the control group(n=26).The treatment group received Alprostadil in-jection(10 μg+250 ml NS, ivgtt) and Mecobalamin injection (0.5 mg+100 ml NS, ivgtt), and the control group received Mecobalamin injection(0.5 mg+100 ml NS, ivgtt).Both of the two groups were treated for 4 weeks and their clinical outcomes were evaluated .Results The baseline information was similar between the two groups ( P>0.05 ) .Seventeen cases were cured , 7 cases improved , 1 case invalid and 1 case deteriorated in the treatment group . Eight cases were cured , 9 cases improved , 7 cases invalid and 2 cases deteriorated in the control group .There was significant difference in the clinical total curative effect between the two groups ( P<0.05 ) .Compared with the same symptoms in the control group , the symptoms of claudication , swelling, pain and hemodynamics were improved in the treatment group after the treatment , and the treatment group were markedly better than the control group in improving the symptoms of claudication , pain and hemodynamics .The peak flow rate of popliteal and dorsal pedal arteries was significantly quicker after the treatment than that before the treatment in the treatment group , which was superior to that in the control group ( P<0.05 ) .No severe adverse reactions were found in the two groups .Conclusion Alpros-tadil combined with Mecobalamin can significantly improve the limb blood supply , alleviate the symptoms of pain , swelling and claudication , which is an effective and safe therapy for Wanger 1~3 level of type 2 DF.