Research of BDNF, Hcy and SS in the diagnosis of vascular dementia after stroke
LI Shao-hui
LI Mao-qing
ZHONG Jun-jie
Abstract：Objective To investigate the value of cerebral blood source of nerve neurotrophic factor ( BD-NF) , homocysteine ( Hcy) and somatostatin ( SS) combined with monitoring in the diagnosis post-stroke vascular de-mentia(VD).Methods Thirty patients with VD after stroke were selected as VD group , 30 patients with cerebral apoplexy ( non vascular dementia ) as stroke group and 30 healthy people as the control group .The risk factors and re-lated history of the VD group and the stroke group were analyzed , and the differences of Hcy , SS and BDNF were compared among the three groups and the levels of SS , Hcy and BDNF were compared among the three subgroups of the VD group with different levels of severity of VD .Results ( 1 ) There was significant difference in the history of hypertension between the VD group and the stroke group (P<0.05);(2)The levels of serum BDNF and SS in the VD group were lower than those in the stroke group and the control group ( P<0.01 );serum level of Hcy in the VD group was significantly higher than that in the stroke group and the control group ( P<0.01 );( 3 ) The levels of serum BD-NF, Hcy and SS among different levels of severity in VD patients were significant different (P<0.01).Conclusion The levels of serum SS , Hcy and BDNF are beneficial to the early diagnosis and assessment of the severity of vascular dementia .
Keywords：Vascular dementiaStrokeCombined monitoring
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 220-223 )