Combined detection of CA125 and HE4 in the diagnosis of ovarian cancer:a Meta analysis
BAI Shan-shan
HE Ya-jun
Abstract：Objective To evaluate the importance of combined detection of tumor markers CA 125 and HE4 in the diagnosis of ovarian cancer .Methods The digital literatures were retrieved from the databases of PubMed , CNKI and VIP to evaluate the significance of the combined detection of the tumor markers CA 125 and HE4 in the di-agnosis of ovarian cancer .Stata 12.0 software was used to conduct the Meta-analysis.Results A total of 11 litera-tures were obtained in the current work with 834 ovarian cancer cases and 1 784 controls.The result showed that the sensitivity, specificity and diagnostic odds ratio(DOR) index of the tumor markers CA125 and HE4 were 0.89[95%CI(0.85,0.92)], 0.13[95%CI(0.09,0.18)] and 44[95%CI(28,71)] respectively in the combined detection of tumor markers CA125 and HE4, while the indices of the sensitivity, specificity, diagnostic odds ratio(DOR) of the marker CA125 that was detected alone were 0.72[95%CI(0.65,0.78)], 0.35 [95%CI(0.27,0.46)] and 10 [95%CI(5,19)] respectively.There were significant differences between the two methods in diagnosing ovarian cancer.Conclusion The combined detection of the tumor markers CA 125 and HE4 may provide more competent and valuable laboratory proofs for the clinical diagnosis of ovarian cancer than the detection of CA 125 alone.
Keywords：CA125HE4Ovarian cancerMeta analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 213-217 )