The expression of cluster of differentiation-24 in cervical carcinoma and cervical intraepithelial neoplasia
Abstract：Objective To investigate the expression of cluster of differentiation-24(CD24) and its correla-tion with pathological types and clinical stages in cervical carcinoma .Methods Forty patients with cervical cancer and 35 patient with cervical intraepithelial neoplasia ( CIN) were collected as experimental group 1 and experimental group 2, respectively, other 20 females with normal cervical were considered as the control group .Streptavidin-perox-idase immunohistochemical technique was used to detect CD 24.Results CD24 protein was mainly located in cellular membrane and cytoplasm of malignant cells .Positive rate was 90%(36/40) in cervical cancer and 42.9%(15/35) in CIN.No positive expression of CD 24 was found in the normal cervical tissues .There were significant differences a-mong the three groups ( P<0.05 ) .The positive rate of CD24 protein was not correlated with the pathological types and clinical stages(P>0.05).Conclusion The expression of CD24 is significantly higher in cervical carcinoma and CIN than that in the normal cervical tissues .The higher expression of CD 24 is not associated with the histopathologi-cal types and the clinical stages .
Keywords：CD24 proteinCervical carcinomaCervical intraepithelial neoplasiaNormal cervical tis -sueImmunohistochemistry
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 192-195 )