The effectiveness and safety of noninvasive sequential mechanical ventilation in the treatment of severe respir-atory failure in elderly patients

LI Hong-jian

doi:10.3969/j.issn.1674-3806.2016.02.15

Abstract：Objective To observe the effectiveness and safety of noninvasive mechanical ventilation in the treatment of severe respiratory failure in elderly patients.Methods Ninety patients with severe respiratory failure treated with mechanical ventilation were divided into the study group and the control group according to the different mechanical ventilation schemes.The study group was conducted with noninvasive sequential mechanical ventilation, while the control group received invasive mechanical ventilation.The blood gas, the clinical effect and the degree of stress reaction were compared between the two groups.Results The success rate of ventilator weaning, ventilator-as-sociated pneumonia, reintubation rate and mortality rate were significantly lower in the study group than those in the control group, with significant differences between the two groups ( P <0.05 ); The heart rate, respiration, pH, PaO2 , PaCO2 , SaO2 in the study group improved significantly better than those in the control group ( P <0.05 );There were significant differences in adrenaline( E) , norepinephrine( NE) , renin( R) , angiotensin( AT) and angio-tensin-Ⅱlevels between the study group and the control group(P<0.05).The total mechanical ventilation time, the hospitalization time, the duration of ventilation, the length of stay in ICU, the sternum sign disappeared time, and the time of PaO2/FiO2 were shorter in the study group than in the control group( P<0.05); The average hospitalization cost of the study group was significantly less than that of the control group( P<0.05) .Conclusion Noninvasive se-quential mechanical ventilation has a better clinical effect and a lower mortality rate in the treatment of severe respira-tory failure.