Clinical application of detecting serum PCT on diagnosis of infectious disease

ZHU Xing-cheng; WANG Dong-ju

doi:10.3969/j.issn.1674-3806.2016.02.11

Abstract：Objective To explore the clinical value of detecting serum PCT, hs-CRP and SAA in distinguis-hing local bacterial infection from systemic bacterial infection, and to provide the experimental basis for the diagnosis and treatment of infectious disease.Methods The serum levels of PCT, hs-CRP and SAA were exmamined in the patients with local bacterial infection(n=92), systemic bacterial infection(n=120) and in the patients without in-fection(n=34).The relationships between the above indicators and bacterial infections were analyzed.ROC method and binary logistic regression were used to analyze the data.Results There were significant differences in the serum levels of PCT, hs-CRP and SAA among the three groups(P<0.05).There were significant differences in the serum levels of PCT, hs-CRP and SAA beween the local bacterial infection group and the systemic bacterial infection group (P<0.05).The serum levels of PCT, hs-CRP and SAA in the patients with systemic bacterial infection was signifi-cantly higher than those in the patients with local bacterial infection and those without infection.The specificity, sen-sitivity and AUC of PCT were higher than those of hs-CRP and those of SAA for diagnosing systemic bacterial infection and for distinguishing local bacterial infection.The regression equation was log( p/1-p) =0.117+0.16 ×PCT+0.01 ×hs-CRP, which was obtained by the binary logistic regression analysis, in which the partial regression coeffi-cient( B) of PCT was the biggest in the equation, indicating that PCT had higher efficiency for distinguishing local bacterial infection from systemic infection.Conclusion The levels of serum hs-CRP, PCT and SAA can be used for the diagnosis of systemic bacterial infection.Compared with CRP, PCT is a good marker for the diagnosis of systemic bacterial infections, especially for the early diagnosis.