Effect of large dose of dexamethasone combined with rituximab on CD4 +CD25 + Treg cells in patients with primary immune thrombocytopenia

CUI Yun-xia

doi:10.3969/j.issn.1674-3806.2015.12.15

Abstract：Objective To investigate the effect of large dose of dexamethasone combined with rituximab on CD4+CD25+ Treg cells in the patients with primary immune thrombocytopenia.Methods One hundred and forty-six patients with ITP were collected and divided into the control group(n =51), dexamethasone group(n =47) and com-bination group(n =48).40 healthy people were taken as the physical examination group.The control group was giv-en prednisone and the dexamethasone group was treated with dexamethasone.The combination group was given dexa-methasone combined with rituximab.CD4 +CD25 + Treg cells were determined in all groups.The levels of CD4 +CD25+ Treg cells were compared among the three groups and the physical examination group before the treatment. The levels of CD4+, CD25+ and CD127 Treg cells were compared among the three groups before the treatment and 2, 4 weeks after the treatment.The curative effect and recurrence were compared among the three groups.Re sults The levels of CD4+CD25+ Treg cells in the control group, dexamethasone group and combination group were signifi-cantly lower than those in the physical examination group.The above indicators were significantly increased after the treatment of 2 and 4 weeks than those before the treatment.The indicators were increased at first and then decreased in the control group and dexamethasone group, but they were gradually increased in the combination group and were significantly higher than those in the control group and dexamethasone group after the treatment of 4 weeks.The total effective rate of the combination group was significantly higher than that of the control group and dexamethasone group (P <0.01).The recurrence rate of the combination group(22.9%) was significantly lower than that of the control group and the dexamethasone group(P <0.01).Conclusion Large dose of dexamethasone combined with rituximab can effectively improve the levels of Treg cells, with a satisfactory long-term curative effect.