Effect of dexmedetomidine combined with propofol on induced abortion under Narcotrend monitoring

doi:10.3969/j.issn.1674-3806.2015.12.14

Abstract：Objective To investigate the effect and safety of dexmedetomidine combined with propofol on in-duced abortion under Narcotrend monitoring.Methods Sixty patients with ASA Ⅰ or Ⅱ, undergoing induced abor-tion, were randomly divided into dexmedetomidine group(group D) and propofol group(group P), with 30 cases in each group.The monitoring of anesthesia depth was given in the two groups.After anesthesia induced under Narco-trend monitoring, group D was injected with dexmedetomidine 0.4 μg/kg within 10 min by intravenous injection, and then injected with propofol 2 mg/kg.Group P was injected with propofol 2.5 mg/kg alone, if necessary, propofol was added.The treatment started after NI dropped to set the value of D2(NI =37 ~46), and the medication was added according to whether the NI was in the target range or not.MAP, heart rate(HR) and pulse oxygen saturation(SpO2 ) were recorded at the time points of pre-anesthesia(T0), loss of consciousness(T1), the palace cavity suction(T2) and recovery(T3).The time of recovery and orientation recovery, the dosage of propofol, anesthesia effect and ad-verse reaction were recorded.Results There were no significant differences in the anesthetic effect between the two groups(P >0.05).HR, MAP and SpO2 at T1 were significantly lower than those at T0(P <0.05); MAP and SpO2 decreased more in group P than those in group D(P <0.05), MAP of group P at T2 was lower than that of group D and at T0(P <0.05).The time of awaken and orientation recovery in group P was longer than that in group D(P <0.05).The dosage of propofol in group P was significantly higher than that in group D(P <0.05).Respiratory de-pression, dizziness and restlessness occurrence rate in group P were significantly higher than those in group D(P <0.05).Conclusion Dexmedetomidine combined with propofol in treatment of painless anesthesia can reduce the dose of propofol and adverse effects, make hemodynamics stable and shorten the duration of recovery.