Meta-analysis of Bmi-1 expression and clinical significance in non-small cell lung cancer
LAI Xiang-li
FENG Guo-sheng
GAO Shan
Abstract：Objective To investigate the association between the expression of B-cell specific moloney leu-kemia virus insertion site 1(Bmi-1) and non-small cell lung cancer(NSCLC).Methods According to the inclusion and exclusion criteria, We independently searched the case-control studies of Bmi-1 and non-small cell lung cancer that published in Pubmed, Embase, Web of Science, CNKI, Wanfang database and VIP database both in Chinese and English until March 2015, and a retrospective review of the literatures was analyzed.We extracted the clinic pathological features of NSCLC relevant to Bmi-1, such as gender, age and histological type.All statistical analysis was performed by the RevMan5.2 Meta-analysis software.Results Eleven case-control studies were eventually re-cruited, including 697 cases of NSCLC patients and 504 cases of the control group.Meta-analysis indicated that the expression level of Bmi-1 in NSCLC was significantly higher than that in the control group(P <0.01).The expression level of Bmi-1 in NSCLC was closely correlated with the degree of differentiation and the lymph node metastasis(P <0.01), but not correlated with the pathological types(P >0.05).Conclusion The detection of Bmi-1 expression level may become a new method for the earlier diagnosis, prognosis and monitoring curative effects of NSCLC.
Keywords：Non-small cell lung carcinoma(NSCLC)B-cell specific moloney leukemia virus insertion site 1(Bmi-1)Meta-analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1148-1153 )