Expressions of CDC2 and PFTK1 in esophageal squamous cell carcinoma and their clinical significances
Abstract：Objective To investigate the expressions of CDC2 and PFTK1 in esophageal squamous cell car-cinoma and to analyze their relationship with biological characteristics of malignant, clinical stage, pathological grade and invasion and metastasis of ESCC and clinical significances.Methods The expressions of CDC2 and PFTK1 in e-sophageal squamous cell carcinoma tissues and their para-cancerous tissues were detected by immunohistochemical SP method.Results The positive rates of CDC2 in esophageal squamous cell carcinoma, para-cancerous tissues were 80.00%, 50.00%(P <0.05), the differences were statistically significant; the positive rates of PFTK1 in esophage-al squamous cell carcinoma, para-cancerous tissues were 53.33%, 30.00%(P <0.05), the differences were statis-tically significant.The expressions of CDC2 and PFTK1 were associated with TNM stage, invasive depth and lymph node metastasis(P <0.05).There was positive correlation between the expressions of CDC2 and PFTK1 in esophage-al squamous cell carcinoma(r =0.367, P =0.004).Conclusion CDC2 and PFTK1 may be involved in the occur-rence and development of esophageal squamous carcinom.
Keywords：CDC2PFTK1Esophageal squamous cell carcinoma
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1142-1145 )