Analysis of the distribution and drug resistance of Gram-negative Bacilli in patients with chronic obstructive pulmonary disease complicated with hospital-acquired pneumonia
Abstract：Objective To study the distribution and drug resistance of Gram-negative bacilli in patients with chronic obstructive pulmonary disease(COPD) complicated with hospital-acquired pneumonia(HAP), and to provide the evidences for clinical diagnosis and treatment.Methods The bacteria were isolated from the specimens in the re-spiratory tract in 68 patients with COPD complicated with HAP from January 2009 to September 2014, and their drug susceptibilities were tested.The distribution and drug resistance of Gram-negative bacilli in the isolated specimens were retrospective analysed.Results One hundred and forty-seven strains of gram-negative bacilli were isolated from 68 patients, including 92 strains of Acinetobacter baumannii (62.6%), 32 strains of Pseudomonas aeruginosa (21.8%), 10 strains of Klebsiella pneumonia(6.8%), and 13 strains of other gram-negative bacilli(8.8%).The drug resistance rates of Acinetobacter baumannii to levofloxacin, ceftazidime, cefepime, imipenem, piperacillin/tazobactam and cefoperazone/sulbactam were 73.9%, 94.6%, 81.5%, 65.2%, 62.0% and 55.4%, respective-ly.The resistance rates of Klebsiella pneumonia to piperacillin, cefuroxime and ciprofloxacin were 50.0%, 60.0%and 90.0% respectively.The resistance rates of Pseudomonas aeruginosa to the above common antibiotics were low-er.Conclusion The common Gram-negative bacilli isolated from the patients with COPD complicated with HAP are Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumonia in which Acinetobacter baumannii is a multidrug-resistant pathogen.Clinicians should pay more attention to the prevention and treatment of infection caused by Acinetobacter baumannii in patients and use antibiotics properly.
Keywords：Chronic obstructive pulmonary disease(COPD)Hospital-acquired pneumonia(HAP)Gram-negative bacilliAcinetobacter baumannii
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1139-1142 )