Analysis of serum complement C1q levels in combination with other laboratory parameters in HIV/AIDS pa-tients prio-and post-treatment
Abstract：Objective To elucidate the serum levels of complement C1q and their correlation with other la-boratory parameters in HIV/AIDS patients prior-and post-treatment.Methods A retrospective study was performed in which 96 HIV/AIDS patients were included from September 2011 to October 2014 in the Fourth People′s Hospital of Nanning in Guangxi Zhuang Autonomous Region and were treated with antiretroviral therapy.The serum comple-ment C1q and other laboratory parameters in the patients were detected and analyzed before and 6 months after the treatment.Results The concentration of serum complement C1q was significantly reduced in HIV/AIDS patients af-ter antiretroviral therapy(P <0.05).Among them, the serum C1q level was elevated in 33 cases after 6 months of the treatment comparing to 63 cases who showed serum C1q reduction(P <0.05).Blood CD3, CD4, CD8 counts, and CD4 /CD8 ratio were elevated while the viral load testing results showed decrease after the treatment comparing with those before the treatment(P <0.01).Conclusion Combination analysis of serum C1q level, T lymphocyte subsets, and viral load is a new and useful clinical laboratory diagnostic strategy and should be considered as a routine monitoring parameter set in HIV/AIDS treatment and prognosis.
Keywords：Human immunodeficiency virus(HIV)Acquired immune deficiency syndrome(AIDS)Complement C1qT lymphocyte subsetsViral load
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1136-1138 )