The influence of hyperbaric on coagulation function and blood cells oxygen in rabbits with renal injury in-duced by ESWL
Abstract：Objective To evaluate the effect of hyperbaric oxygen on the coagulation function and blood cell changes in the treatment of rabbit renal injury induced by extracorporeal shock wave lithotripsy(ESWL).Methods Twelve rabbits were randomly divided into the control group and the experimental group.The control group were given ESWL impact on the left idney for 1 500 times(capacitance 0.4 μF, voltage 18 kV) to cause kidney damage, but without hyperbaric oxygen treatment.The experimental group receival hyperbaric oxygen treatment 0.2 MPa(2.0 ATA) for continuous 5 days.The changes in blood white blood cell(WBC), red blood cell(RBC), platelet(PLT), prothrombin time(PT), and activated part clotting live enzyme time(APTT) were observed before the treatment and 1, 3, 7 days after the treatment respectively.Results There was no significant difference in RBC between the two groups after the hyperbaric oxygen treatment(HBOT)(P >0.05).WBC, PT, APTT were significantly decreased in the experimental group at 1, 3 days after the HBOT compared with those in the control group, PLT were elevated in the experimental group(P <0.05), and almost recovered back to their original levels 7 days after the HBOT(P >0.05).Conclusion Hyperbaric oxygen reduces inflammation reaction, but does not induce or aggravate renal severe bleeding in the treatment of renal injury induced by ESWL.By increasing blood flow and oxygen supply to the impor-tant visceral organs.
Keywords：Extracorporeal shock wave lithotripsy ( ESWL)Kidney damageHyperbaric oxygen (HBO)Coagulation functionBlood cellRabbit
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1117-1120 )