Study of the levels of G6PD activity in different types of thalassemia in Guangxi

doi:10.3969/j.issn.1674-3806.2015.11.16

Abstract：Objective To analyse the levels of G6PD activity in different types of thalassemia in Guangxi and to study their association with thalassemia.Me thods One hundred and thirteen negative thalassemia samples and 248 different types of thalassemia samples were analyzed by gene analysis and were detected for G6PD activity.Re-sults The levels of G6PD activity was (6.76 ±2.28)U/gHb in the negative thalassemia group, (9.00 ±3.67 )U/gHb inαthalassemia group, (10.98 ±6.25) U/gHb in βthalassemia group, and (9.09 ±2.96) U/gHb in αβcomplex thalassemia group, with significantly differences compared with the negative thalassemia group ( P <0.05 ) .The G6PD activity levels ofαthalassemia in silent, trait and Hb H groups were (6.67 ±1.65)U/gHb,(8.89 ±2.12)U/gHb, (12.7 ±5.44)U/gHb respectively;of βthalassemia in trait and intermedia groups were (9.68 ±3.71)U/gHb and (18.43 ±10.71)U/gHb.There were significant differences in the levels of G6PD between the different types of αthalassemia andβthalassemia inαthalassemia and βthalassemia groups(P<0.05).Conclusion Different levels of G6PD activity go with different types of thalassemia, the more severe anemia the higher G6PD activity.