Effects of cinepazide maleate on inflammatory factors and neural functional defects in patients with acute cer-ebral infarction

MA Xue-li

doi:10.3969/j.issn.1674-3806.2015.11.15

Abstract：Objective To study the effects of cinepazide maleate on inflammatory factors and neural func-tional defects in patients with acute cerebral infarction( ACI) .Methods Eighty patients with ACI were randomly di-vided into two groups, with 40 cases in each group.The control group(n=40) was given routine treatment(dehydra-tion, anticoagulation, protecting brain, hyperbaric oxygen and symptomatic treatment) and the observation group( n=40) was given cinepazide maleate based on the same treatment in the control group.Both of the two groups were treated for 14 days.The levels of IL-6, TNF-α, sICAM-1, MMP-9, infarct volume and NIHSS score were detected in each group before and after treatment and their clinical efficacy were evaluated.Results After 14 days of the treat-ment, the efficacy was excellent in 19 cases, good in 14 cases, improved in 6 cases in the observation group, and in-valid in 1 case;the efficacy counterparts in the control group were 10, 12, 10 and 8 respectively.The effect of the observation group was better than that of the control group( P<0.05) .There were no significant differences between the two groups in the levels of IL-6, TNF-α, sICAM-1, MMP-9, infarct volume and national institute health stroke scale(NIHSS) score before the treatment(P>0.05).After 14 days of the treatment, the above indicators in the two groups were significantly improved than those before the treatment(P<0.01), however the indicators were improved more obviously in the observation group(P<0.01);There was no significant difference in the incidence of adverse reactions between the observation group(15%) and the control group(10%)(χ2 =0.4571, P>0.05).Conclusion Cinepazide maleate is safe and effective in the treatment of acute cerebral infarction.It can reduce infarction area, improve prognosis and reduce the levels of inflammatory factors (IL-6, TNF-α, sICAM-1, MMP-9), which may be one of the mechanisms of action.