Prospective study of serious oral mucositis risk factors during radiotherapy for patients with nasopharyngeal carcinoma
Abstract：Objective To study the high risk factors of serious oral mucositis caused by radiotherapy for the patients with nasopharyngeal carcinoma( NPC) , and to seek for the early treatment and prevention of serious oral mu-cositis, and to establish a predictive model of prognostic index( PI) for physicians to give individualized treatment. Methods The clinical factors of 221 NPC patients with oral mucositis were analyzed by univariate analysis and mul-tifactorial COX regression.PI equation was built on basis of the COX regression mode1.According to PI values, the patients were classified into 2 different risk groups.The incidence rate of serious oral mucositis was compared between the two groups.Results Multifactorial COX regression showed that chemotherapy, bad oral cavity and conventions radiotherapy were the high risk factors of serious oral mucositis.There was significant difference in the incidence rate of serious oral mucositis between the two groups classified by PI values(P<0.01).Conclusion Chemotherapy, bad oral cavity and conventions radiotherapy are high risk factors of serious oral mucositis after radiotherapy for NPC.Ear-ly treatment and preventive actions have some preventive effects on it.PI values may be useful in predicting serious o-ral mucositis caused by radiotherapy for NPC and provide the valuable information for physicians to give individualized treatment.
Keywords：Nasopharyngeal carcinomaRadiotherapyOral mucositisRisk factorsCOX regres-sionPrognostic index
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1041-1046 )