The effect of Dahuangzhechong capsule on matrix metalloproteinase-2 activity in rats with hepatic fibrosis
Abstract：Objective To investigate the effect of Dahuangzhechong capsule on matrix metalloproteinase-2 ( MMP-2) activity in rats with hepatic fibrosis.Methods The collagen deposition and MMP-2 activity in the liver tis-sues were detected by Sirius red staining and zymography respectively.Results With the severity of liver fibrosis, the rising of MMP-2 activity in Dahuangzhechong capsule group was significantly lower than that in the liver fibrosis model group(P<0.05), but greater than that in the control group(P<0.05).Conclusion Dahuangzhechong cap-sule has a depressant effect on MMP-2 activity and inhibits the development of hepatic fibrosis in rats.
Keywords：Dahuangzhechong capsuleHepatic fibrosisMatrix metalloproteinase-2( MMP-2)RatZymography
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1036-1038 )