Effe cts of two kinds of maintenane therapy on treating recurrent vulvovaginal acndidiasis

doi:10.3969/j.issn.1674-3806.2015.11.08

Abstract：Objective To observe the therapeutic effects of two kinds of maintenance therapy on treating re-current vulvovaginal candidiasis( RVVC) and to find a maintenance therapic method with shorter course of treatment and better curative effect.Methods One hundred and twelve patients with RVVC were randomly divided into the ob-servation group(n=56) and the control group(n=56).The observation group was simply given vitamin C tablets in vagina during maintenance therapy for three months; The control group was treated with oral fluconazol and vaginal suppository of clotrimazole for six months.The clinical efficacy, adverse reactions and recurrence rate were compared between the two groups.Results The total effective rates were 96.4%and 98.2%in the observation group and the control group respectively( P>0.05);Vaginal pain occured in five patients in the observation group (8.9%) ,while more adverse reactions including nausea, vomiting and vaginal burning sensation occur in thirteen patients in the con -trol group(23.2%) , with a significant difference in adverse reaction rate between the two groups ( P<0.05 ) .The disease reoccurred in two cases ( 3.6%) in the observation group one year after the treatment, while three cases (5.4%) in the control group, without a significant difference between the two groups(P>0.05).Conclusion Ex-ternal use of vitamin C tablets in vagina has some advantages of a shorter course, satisfactory curative effect and less drug adverse reactions for the treatment of RVVC.