The effect of noninvasive mechanical ventilation on the levels of serum in patients with BNP and ET-1 chronic ;pulmonary heart disease complicated with respiratory failure
Abstract：Objective To analyze the effect of noninvasive mechanical ventilation on the levels of serum BNP and ET-1 in patients with chronic pulmonary heart disease complicated with respiratory failure.Methods Eight-y patients with chronic pulmonary heart disease complicated with respiratory failure were collected and were randomly divided into the experimental group(n=40) and the control group(n=40).The control group was given convention-al treatment and the experimental group was treated with additional noninvasive mechanical ventilation.The clinical curative rate, blood gas analysis and BNP and serum ET-1 levels were compared between the two groups 72 hours af-ter the treatment.Results The clinical symptoms, signs and blood gas analysis results improved significantly in the experimental group 72 hours after the treatment, among which SaO2 , PaO2 significantly increased while PaCO2 , HR and RR decreased significantly(P<0.05).BNP and ET-1 levels of the experimental group decreased with the im-provement of symptoms of hypoxia and carbon dioxide retention(P<0.01, P<0.05), which was significantly better than the control group.BNP and ET-1 levels were positively correlated.BNP and ET-1 and partial pressure of oxygen were negatively correlated.Pressure was positively correlated with carbon dioxide.Conclusion Noninvasive mechan-ical ventilation can improve ventilation function in patients with chronic pulmonary heart disease complicated with re-spiratory failure, reduce the serum BNP and ET-1 levels and improve the clinical efficacy.
Keywords：Noninvasive mechanical ventilationChronic pulmonary heart diseaseRespiratory failureBrain natriuretic peptide( BNP)Endothelin-1( ET-1)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 946-949 )