Changes of the levels of Th1/Th2 subpopulations and the relevant inflammatory cytokines expression in pa-tients with cervical cancer and cervical intrepithelium neoplasia
DONG Yong-zhan
WANG Xiang
Abstract：Objective To detect the expression levels of Th1/Th2 subpopulations and Th1 cytokines inter-leukin-2(IL-2), interferon-γ(IFN-γ) and Th2 cytokines IL-4, IL-6, IL-10 in the serum of patients with cervical carcinoma, hysteromyoma and the healthy controls, and to provide the basis for the early diagnosis of cervical cancer and cervical intrepithelium neoplasia.Methods The peripheral blood was collected from 40 cases with cervical carci-noma, and other 40 cases with cervical intrepithelium neoplasia and 50 healthy people.Th1 cytokines interleukin-2 ( IL-2) , interferon-γ( IFN-γ) and Th2 cytokines IL-4, IL-6, IL-10 in the serum of all cases were detected using ELISA kit.Flow cytometry was used to detect the ratio of Th1/Th2 subpopulations.Results The expression levels of IL-2, IFN-γdecreased, and IL-4, IL-6, IL-10 increased, the ratio of Th1/Th2 decreased in the cervical cancer group and CIN group compared with those in the control group(P<0.05).Th1 cytokines reduced more and Th2 cy-tokines rose more in CIN group than those did in the cervical cancer group(P<0.05).Conclusion Th1 cytokines decrease while Th2 cytokines increase, and the ratio of Th1/Th2 decreases in the patients with cervical cancer.The expression levels of Th1 and Th2 are associated with tumor pathological grade, which reveals that Th1/Th2 plays a vi-tal role in the development of cervical carcinoma,and could be helpful to determine and monitor the tumors properly.
Keywords：Cervical carcinomaCervical intrepithelium neoplasia( CIN)Th1/Th2Inflammatory cy-tokines
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 943-946 )