Value of retraction phenomenon at three-dimensional ultrasonography in diagnosis and prognosis evaluation ;in breast lesions

doi:10.3969/j.issn.1674-3806.2015.09.03

Abstract：Objective To investigate the value of retraction phenomenon at three-dimensional ultrasonogra-phy(3D-US) in diagnosis and prognosis evaluation in breast lesions .Methods 165 patients with breast lesions who underwent 3D-US examination were included .The presence of the retraction phenomenon in the coronal plane was e-valuated.Pathologic prognostic factors , including tumor size , histologic grade , lymph node status , estrogen receptor (ER), progesterone receptor(PR) status, human epidermal growth factor receptor 2(Cerb-B2) and Ki-67 expression were determined .The correlation of the retraction phenomenon and prognostic factors was analyzed .Results The sensitivity and specificity of retraction phenomenon in the diagnosis of breast cancers were 67.7%and 93.1%respec-tively.The detection rates of the retraction phenomenon in the invasive cancer and the non -invasive cancer were 80.3%and 11.8%( P<0.001 ) .The retraction phenomenon was correlated to the tumor size , histologic grade , es-trogen and progesterone receptor status .Compared with the breast cancer without the retraction phenomenon , the tumor size with the retraction phenomenon was more likely to show a smaller diameter less than 2 cm(P<0.05), a lower histologic grade with grade Ⅱ( P<0.05 ) , and a higher positive rate of ER and PR ( P<0.05 ) .The lymph node status and the expression of the CerB-2 and Ki-67 in the two groups had no significant difference ( P>0.05 ) . Conclusion The retraction phenomenon of three-dimensional US may be useful in the diagnosis and prognosis evalu-ation in breast lesions .