Comparison of different doses of hepatitis B immune globulin in blocking infection of hepatitis B virus by mother-to-fetus transmission for newborns
XIE Ruo-xin
YANG Jie-fang
HUO Le-ying
Abstract：Objective To explore the efficacy of different doses of hepatitis B immune globulin in blocking infection of hepatitis B virus by mother-to-fetus transmission for newborns .Methods 124 newborns who were born by HBsAg-positive mothers in our hospital were divided into single positive group (n=60) and double positive group(n=64 ) .The patients in the double positive group were randomly divided into a small dose double positive subgroup ( n=30) and a big dose double positive subgroup (n=30), and the patients in the single positive group were randomly di-vided into a small dose double positive subgroup (n=32) and a big dose double positive subgroup (n=32).The big dose groups were intramuscularly injected with HBIG 200 U and the small dose groups were intramuscularly injected with HBIG 100 U, with all groups in combination of hepatitis B vaccine within 6 hours after childbirth .HBV serologi-cal markers(HB 5 tests)were detected at the age of one.Results There were no significant differences in blocking rate of vertical transmission of hepatitis B between the large dose (200 U) and the small dose(100 U) of HBIG in both double positive group and single positive group .Conclusion Newborns of HBsAg-positive mothers should be in-jected with HBIG in time either in dose of 100 U or 200 U.
Keywords：Hepatitis B immune globulinHepatitis B virusVertical transmission
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 754-757 )