Effects of Shenfu injection on hemodynamics in patients with coronary heart disease by FloTrac/Vigileo Sys-tem during induction of general anesthesia

doi:10.3969/j.issn.1674-3806.2015.08.11

Abstract：Objective To observe the effects of Shenfu injection on hemodynamics in patients with heart dis -ease by FloTrac/Vigileo System during induction of general anesthesia .Methods 50 patients with coronary heart dis-ease but without heart operation were randomly divided into Shenfu group and control group , with 25 cases in each group.Shenfu group was intravenously injected with Shenfu injection 1 ml/kg before the induction of anesthesia , and the control group was injected with lactated Ringer′s solution 1 ml/kg in the same way as Shenfu group .Anesthesia induction was performed in both of the groups after 5 min of drug injections .The method of anesthesia induction and maintenance was the same as that in the two groups .Mean arterial pressure(MAP), heart rate(HR), heart output (CO), cardiac index(CI), stroke volume(SV) and stroke volume variation(SVV) were monitored and calculated by FloTrac at T0(baseline level), T1(after injecting Shenfu or lactated Ringer′s solution ), T2(1 min before intuba-tion), T3(tracheal intubation), T4(1 min after tracheal intubation) and T5(5 min after trachea intubation).Results There were no significantly differences between the two groups at T 0, T1(P>0.05);MAP, HR, CO, CI and SV of both groups were significantly decreased at T2 compared with those at T0(P<0.05).CO, CI, SV of Shenfu group were significantly higher than those of the control group ( P<0.05 ); SVV of the control group was significantly in-creased and significantly higher than that of Shenfu group (P<0.05).At T3 and T4, MAP, HR, CO, CI and SV of both groups were increased , with MAP and HR of the control group being increased more than those of Shenfu group (P<0.05);At T5, MAP, HR, CO, CI and SV of Shenfu group turned to the levels at T 0, while those of the con-trol group were lower than the levels at T 0 ( P<0.05 ) .Conclusion Shenfu injection is effective in attenuating the decrease of CO during the induction of anesthesia ,and beneficial to maintaining hemodynamics stability .