Clinical effect of thioctic acid combined with pregabalin on painful diabetic neuropathy
GENG Xiang-hua
Abstract：Objective To explore the clinical effect of thioctic acid combined with pregabalin on painful dia -betic neuropathy .Methods 84 patients with painful diabetic neuropathy were randomly divided into the control group and the observation group , with 42 cases in each group .The control group was treated with thioctic acid and the ob-servation group was treated with thioctic acid combined with pregabalin .All of the courses of the treatment were 4 weeks.The patients′pain degree, nerve conduction velocity and occurrence of adverse reactions were observed before and after the treatment .Results The reduction of VAS score in the observation group was obviously better than that in the control group ( P<0.01 ) .The nerve conduction velocity was faster in both of the two groups after the treatment than that before the treatment .There was no significant difference between the two groups ( P>0.05 ) .In the obser-vation group, the clinical effect was excellent in 5 cases, good in 35 cases and invalid in 2 cases.In the control group, the clinical effect was excellent in 3 cases, good in 31 cases and invalid in 8 cases.The curative effect of the observation group was better than that of the control group ( t=1.88 ,P<0.05 ) .The occurrence rate of adverse reac-tions is not significantly different between the two groups ( P>0.05 ) .No serious adverse reactions occurred in the two groups.Conclusion The thioctic acid combined with pregabalin in the treatment of the painful diabetic neuropathy is safe and effective to relieve pain and improve therapeutic effect .
Keywords：Painful diabetic neuropathyThioctic acidPregabalinCurative effect
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 736-739 )