Influences of borneol and muscone on blood-brain barrier permeability of nerve growth factor
Abstract：Objective To explore the influences of borneol and muscone on blood-brain barrier permeability of nerve growth factors.Methods Thirty-two Wistar rats aged 7 days old were divided into the muscone group, borneol group, control group and borneol+muscone group, with eight rats in each group.The levels of nerve growth factors passing the blood-brain barrier and neural function behavior scores of the patients in the four groups were analyzed and compared . Results The levels of nerve growth factors in Evans blue, brain tissue and blood of rats in the borneol+muscone group were higher than those in the other three groups .Neural function behavior score of rats in the borneol+muscone group was lower than that in the other three groups(P<0.01).There were no significant differences in the content of Evans blue, level of nerve growth factors and neural functional behavior scores between the borneol group and the muscone group (P>0.05).The content of Evans blue, level of nerve growth factors, neural function behavior scores in the borneol group and the muscone group were higher than those in the control group(P<0.01).Conclusion Muscone and borneol can raise the permeability of blood-brain barrier and get nerve growth factors across the blood-brain barrier better.
Keywords：BorneolMusconeNerve growth factorBlood-brain barrier permeability
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 728-731 )