The therapeutic effect and safety of amlodipine and atorvastatin calcium tablets on hypertension with coro-nary heart disease

CHEN Wei; CHEN Ci

doi:10.3969/j.issn.1674-3806.2015.07.15

Abstract：Objective To observe the clinical effect and safety of amlodipine and atorvastatin calcium tablets on the patients with hypertension and coronary heart disease .Methods 100 patients with hypertension and coronary heart disease were randomly selected in our hospital from July 2012 to July 2014 and randomly divided into the control group and the observation group , with 50 cases in each group .The control group received nifedipine treatment and the observation group was given amlodipine and atorvastatin calcium tablets .The incidence of blood pressure , blood lipid, clinical curative effect and adverse reaction were compared between the two groups .Results In the 50 cases of the observation group , 34 cases had markedly effective result , 13 cases had effective results and 3 cases had no effects.In the control group, 13 cases had markedly effective results , 22 cases had effctive results and 15 cases were invalid.Tsystolic blood pressure, diastolic blood pressure, TG and LDL-C were significantly lower in the observation group than those in the control group after the treatment ( P<0.05 ) .And HDL-C was higher in the observation group than that in the control group ( P<0.05 );The overall incidence of adverse reactions in the observation group was sig-nificantly lower than that in the control group (4.0%vs 26.0%)(P<0.05).Conclusion Amlodipine and atorvas-tatin calcium tablets is a safe and effective treatment in controling blood pressure and improving the blood lipid level on patients with hypertensive and coronary heart disease .