The effect of onglyza combined with metformin on the pancreatic βcell function of the senile patients with type 2 diabetes mellitus
ZHAO Shi-ye
Abstract：Objective To explore the effect of onglyza combined with metformin on the pancreatic βcell function of the senile patients with type 2 diabetes mellitus .Methods 92 senile patients with type 2 diabetes mellitus were randomly divided into the observation group and the control group , with 46 cases in each group .The patients in the control group were treated with metformin combined with placebo and the patients in the observation group were treated with metformin combined with onglyza .FPG, 2hPG, HbA1c, BMI and serum C-peptide levels of the patients were compared between the two groups before and 12 weeks after the treatment .The adverse reactions during the ther-apy were compared between the two groups .Results The FPG, 2hPG, HbA1c, BMI, fasting serum C-peptide and postprandial 2 h serum C-peptide level of the patients in the observation group were improved better than those of the patients in the control group ( P<0.01 ) .The fasting serum C-peptide and postprandial 2 h serum C-peptide level of the patients in the observation group were significant different before and after the treatment ( P<0.01 ) , and there was no significant difference in the adverse reactions between the two groups during the therapy ( P>0.05) .Conclu-sion Onglyza combined with metformin on the treatment for the senile patients with type 2 diabetes mellitus can low-er the fasting and postprandial blood glucose and improve their pancreatic βcell function ,control weight and lower hypoglycemia occurrence risk .
Keywords：Type 2 diabetes mellitusSenile peopleOnglyzaCurative effect
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 642-644 )