Changes of serum immune levels and their clinical significances in children with severe HFMD
LIN You-qing
Abstract：Objective To explore the changes of serum immune levels and their clinical significances in children with severe hand-foot-and-mouth disease(HFMD).Methods 85 cases with HFMD were selected, among whom 45 cases had severe HFMD and 40 cases had ordinary HFMD .Other 30 cases of healthy children were selected as the control group .Serum immunoglobulin levels and serum cytokine levels of the three groups were detected .The changes and clinical significances of serum immune levels in children with severe HFMD were analyzed .Results IgM, IgG and IgA levels in both the severe group and the ordinary group were lower than those in the control group (P<0.01).IgM and IgA levels in the severe group were lower than those in the ordinary group(P<0.01).IL-1β, TNF-α, IL-6, IL-10 levels in the severe group were higher than those in the ordinary group ( P<0.01), and all these indica-tors in both of the two groups were higher than those in the control group (P<0.01).Conclusion Children with severe HFMD serum cytokines are significantly increased , indicating that the virus in the body cause a strong inflammatory re-sponse and the inflammatory reaction;and that the decrease of immunoglobulin levels shows immune function disorders .
Keywords：Hand-foot-and-mouth disease ( HFMD)SerumImmunoglobulinCytokines
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 639-641 )