The diagnostic value of bronchoalveolar lavage fluid galactomannan antigen assay and 1, 3 beta-D-glucan as-say for invasive aspergillosis
CHEN Hui-peng
ZHONG Ru-zhu
LI Li
Abstract：Objective To investigate the value of galactomannan antigen assay and 1, 3 beta-D-glucan assay in bronchoalveolar lavage fluid ( BALF) in the early diagnosis for invasive aspergillosis .Methods A total of 32 pa-tients with invasive aspergillosis and 24 patients with bacterial infections were performed G test and GM test and the levels of BG antigen and GM antigen were measured .The sensitivity, specificity, positive predictive values and nega-tive predictive value were calculated .The ROC curve was used to compare the diagnostic values of G test and GM test, with kappa values to illustrate the consistency of G test and GM test .Results The sensitivity, specificity, posi-tive predictive values and negative predictive value were 84.38%, 83.33%, 87.10%and 80.00%respectively in G test , and 81.25%, 87.50%, 89.66%and 77.78%respectively in GM test .The levels of BG antigen and GM anti-gen in patients with invasive aspergillosis were significantly higher than those in patients with bacterial infection ( P<0.05 ) .The areas under the ROC curve were respectively 0.839 and 0.844 in G test and GM test , with kappa value 0.57 ( P>0.05 ) .The sensitivity of G test was slightly higher than that of GM test , while the specificity of the G test was slightly lower than that of GM test , without a significant difference ( P>0.05 ) .Conclusion BALF G test and GM test is very important for early diagnosis of invasive aspergillosis .
Keywords：Galactomannan(13)-β-D-glucanInvasive aspergillosisBronchoalveolar lavage fluid
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 623-627 )