Efficacy and safety of half-dose reteplase as thrombolytics on more than 75-year-old patients with acute myo-cardial infarction
Abstract：Objective To investigate the efficacy and safety of half-dose reteplase as thrombolytics on more than 75-year-old patients with ST-segment elevation myocardial infarction ( STEMI) .Methods 65 patients more than 75-year-old with STEMI were randomly divided into the observation group ( n=32 ) and the control group ( n=33 ) . Both groups were treated with the primary medication , and the observation group received additional half-dose rete-plase.The coronary artery recanalization rate and the occurrence of major adverse cardiovascular events (MACE), bleeding complications and thrombocytopenia were compared between the two groups .Results The coronary artery recanalization rate in the observation group was significantly higher than that in the control group (68.8%vs 15.2%, P<0.01 ) .The death rate in the observation group was significantly lower than that in the control group ( 3.1% vs 24.2%,P<0.05).There were no significant differences in the incidences of heart failure , cardiogenic shock and is-chemia between the two groups ( P>0.05 ) .The incidence of mild bleeding complication in the observation group was higher than that in the control group (28.1% vs 6.1%,P<0.05).There were no moderate to severe bleeding complications in the two groups .Conclusion Half dose of reteplase as thrombolytics is effective and safe for more than 75-year-old patients with STEMI .
Keywords：Myocardial infarctionReteplaseAged
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 614-617 )